Research

Currently, the scope of Department’s research is pharmacokinetics, as well as its clinical application. We have successfully developed numerous methods enabling determination of xenobiotics such as non-steroid anti-inflammatory drugs, cytostatic drugs, macrolide antibiotics, antithrombotic drugs and endogenous compounds (glucocorticoids, vitamins). Due to an urgent need for personalized therapy, we are also investigating genetic polymorphisms that might influence drug’s pharmacokinetics.

At present, we are cooperating with several Departments from within Poznan University of Medical Sciences:

  • Department of Pediatric Hematology and Oncology and Hematopoietic Stem Cell Transplantation
  • Department of Internal Medicine, Metabolic Disorders and Hypertension
  • Department of General and Vascular Surgery
  • Department of Internal Medicine, Division of Cardiology-Intensive Therapy
  • Department of Pharmaceutical Biochemistry
  • Department of Clinical Chemistry and Molecular Diagnostics
  • Department of Inorganic and Analytical Chemistry
  • Department of Clinical Pharmacy and Biopharmacy
  • Department of Pharmaceutical Technology
  • Department of Forensic Medicine
  • Central Laboratory of Gynecology-Obstetrics Hospital

and from other Universities and Hospitals in Poland:

  • Department and Clinic of Pediatric Oncology, Haematology and Bone Marrow Transplantation of Wroclaw Medical University
  • Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz
  • Department of Transplantology and General Surgery, District Hospital in Poznan

Our knowledge and experience resulted in cooperation with pharmaceutical industry in the past twenty years:

  • Jelfa S.A. (Jelenia Góra, Poland) –investigation of bioavailability of piroxicam, indobufen, gliclazide,isoniazide, moclobemide, indapamide, mesalazine,hydocortizone, loratadine and pharmaceutical availability of gliclazide 
  • Adamed sp. z.o.o. (Warsaw, Poland) – investigation of bioavailability of gliclazide, amlodipine, losartane, propylthiouracil, nimesulide, furagin and pharmaceutical availability of alendronate and famotidine 
  • Biofarm sp. z.o.o. (Poznan, Poland) – simulation of pharmacokinetic parameters for tianepine and vinpocetine modified-release formulations 

Currently, we are cooperating with:

  • Medac GmbH (Hamburg, Germany) – kinetics and pharmacokinetics of treosulfan and its metabolites

 

Doctoral dissertations : link

 

Equipment:

  • HPLC Agilent coupled with an UV detector
  • HPLC Agilent coupled with FLD detector
  • HPLC Spectra Physics coupled with UV and FLD detector
  • HPCE with DAD detector
  • Specol UV-VIS
  • Spectrophotometer SP-830 Plus
  • Tensiometer Lauda TD1C
  • Cryoscope 800cl